| | 投手 | Activated (The Cleveland Guardians activated RHP Pedro Avila.) |
| | 投手 | Sent to Minors (The Cleveland Guardians optioned RHP Wes Parsons to the minors.) |
| | 二壘手 | Placed on 60-Day IL (The Cleveland Guardians transferred SS Angel Martínez from the 10-day injured list to the 60-day injured list. ) |
| | 投手 | Sent to Minors (The Cleveland Guardians optioned RHP Xzavion Curry to the minors.) |
| | 投手 | Traded (The San Diego Padres traded RHP Pedro Avila to the Cleveland Guardians.) 從 |
| | 投手 | Placed on 15-Day IL (The Cleveland Guardians placed RHP Eli Morgan on the 15-day injured list.) |
| | 投手 | Recalled From Minors Rehab (The Cleveland Guardians recalled RHP Wes Parsons from the minors.) |
| | 投手 | Activated (The Cleveland Guardians activated RHP Ben Lively from the 15-day injured list.) |
| | 投手 | Sent to Minors (The Cleveland Guardians optioned RHP Peter Strzelecki to the minors.) |
| | 投手 | Activated (The Cleveland Guardians activated RHP Xzavion Curry from the 15-day injured list.) |
| | 投手 | Sent to Minors (The Cleveland Guardians assigned SP Wes Parsons to the minors.) |
| | 投手 | Recalled From Minors Rehab (The Cleveland Guardians recalled 27th man RHP Wes Parsons from the minors.) |
| | 投手 | Traded (The Toronto Blue Jays traded RHP Wes Parsons to the Cleveland Guardians.) 從 |
| | 投手 | Placed on 15-Day IL (The Cleveland Guardians placed RHP Shane Bieber on the 15-day injured list with a season ending elbow injury.) |
| | 投手 | Recalled From Minors Rehab (The Cleveland Guardians recalled RHP Peter Strzelecki from the minors.) |
| | 投手 | Placed on 15-Day IL (The Cleveland Guardians placed RHP Xzavion Curry on the 15-day injured list.) |
| | 投手 | Recalled From Minors Rehab (The Cleveland Guardians selected the contract of RHP Tyler Beede from the minors.) |
| | 投手 | Placed on 60-Day IL (The Cleveland Guardians placed RHP Ben Lively on the 60-day injured list.) |
| | 投手 | Placed on 15-Day IL (The Cleveland Guardians placed LHP Sam Hentges on the 15-day injured list.) |
| | 投手 | Traded (The Texas Rangers traded RHP Zak Kent to the Cleveland Guardians.) 從 |
| | 投手 | Placed on 60-Day IL (The Cleveland Guardians placed RHP James Karinchak on the 60-day injured list.) |
| | 二壘手 | Placed on 10-Day IL (The Cleveland Guardians placed INF Angel Martínez on the 10-day injured list.) |
| | 投手 | Recalled From Minors Rehab (The Cleveland Guardians selected the contract of RHP Carlos Carrasco from the minors.) |
| | 投手 | Placed on 15-Day IL (The Cleveland Guardians placed RHP Gavin Williams on the 15-day injured list.) |
| | 投手 | Traded (The Arizona Diamondbacks traded RHP Peter Strzelecki to the Cleveland Guardians. The Guardians then optioned him to the minors.) 從 |
| | 投手 | Placed on 60-Day IL (The Cleveland Guardians placed RHP Trevor Stephan on the 60-day injured list.) |
| | 中外野手 | Sent to Minors (The Cleveland Guardians sent OF Myles Straw outright the minors.) |
| | 捕手 | Released (The Cleveland Guardians released C Eric Rodriguez.) |
| | 投手 | Released (The Cleveland Guardians released LHP Adam Scott.) |
| | 投手 | Released (The Cleveland Guardians released RHP Jason Bilous.) |
| | 投手 | Released (The Cleveland Guardians released RHP Tyler Zuber.) |
| | 捕手 | Released (The Cleveland Guardians released C Michael Berglund.) |
| | 三壘手 | Other Transaction (Rule 5 draft pick INF Deyvison De Los Santos cleared waivers and was returned to the Arizona Diamondbacks.) |
| | 三壘手 | Sent to Minors (The Cleveland Guardians sent INF Daniel Schneemann to the minors.) |
| | 投手 | Sent to Minors (The Cleveland Guardians sent LHP Anthony Gose to the minors.) |
| | 游擊手 | Sent to Minors (The Cleveland Guardians optioned INF José Tena to the minors.) |
| | 投手 | Sent to Minors (The Cleveland Guardians sent RHP Adam Oller to the minors.) |
| | 投手 | Sent to Minors (The Cleveland Guardians sent RHP Jack Leftwich to the minors.) |
| | 投手 | Sent to Minors (The Cleveland Guardians sent LHP Anthony Banda to the minors.) |
| | 捕手 | Sent to Minors (The Cleveland Guardians sent C Dom Nuñez to the minors.) |
| | 中外野手 | Sent to Minors (The Cleveland Guardians sent OF Lorenzo Cedrola to the minors.) |
| | 投手 | Sent to Minors (The Cleveland Guardians sent RHP Jaime Barría to the minors.) |
| | 三壘手 | Sent to Minors (The Cleveland Guardians sent INF Raynel Delgado to the minors.) |
| | 一壘手 | Sent to Minors (The Cleveland Guardians sent INF Micah Pries to the minors.) |
| | 一壘手 | Sent to Minors (The Cleveland Guardians sent INF Kyle Manzardo to the minors.) |
| | 投手 | Sent to Minors (The Cleveland Guardians optioned LHP Joey Cantillo to the minors.) |
| | 左外野手 | Sent to Minors (The Cleveland Guardians optioned OF Jhonkensy Noel to the minors.) |
| | 三壘手 | Sent to Minors (The Cleveland Guardians optioned INF Juan Brito to the minors.) |
| | 右外野手 | Sent to Minors (The Cleveland Guardians optioned OF Johnathan Rodriguez to the minors.) |
| | 投手 | Sent to Minors (The Cleveland Guardians optioned RHP Daniel Espino to the minors.) |
| | 右外野手 | Sent to Minors (The Cleveland Guardians optioned OF George Valera to the minors.) |
| | 投手 | Non-roster Invitee (The Cleveland Guardians invited RHP Adam Oller to spring training.) |
| | 投手 | Non-roster Invitee (The Cleveland Guardians invited RHP Jack Leftwich to spring training.) |
| | 捕手 | Non-roster Invitee (The Cleveland Guardians invited C Eric Rodriguez to spring training.) |
| | 投手 | Non-roster Invitee (The Cleveland Guardians invited RHP Mason Hickman to spring training.) |
| | 投手 | Non-roster Invitee (The Cleveland Guardians signed RHP Tyler Zuber to a minor league contract with an invitation to spring training.) |
| | 捕手 | Non-roster Invitee (The Cleveland Guardians signed C Dom Nuñez to a minor league contract with an invitation to spring training.) |
| | 投手 | Non-roster Invitee (The Cleveland Guardians signed LHP Anthony Banda to a minor league contract with an invitation to spring training.) |
| | 投手 | Signed (The Cleveland Guardians signed RHP Carlos Carrasco to a minor league contract with an invitation to spring training.) |
| | 中外野手 | Non-roster Invitee (The Cleveland Guardians signed OF Lorenzo Cedrola to a minor league contract with an invitation to spring training.) |
| | 投手 | Released (The Cleveland Guardians released RHP Justin Lewis.) |
| | 一壘手 | Non-roster Invitee (The Cleveland Guardians invited INF Kyle Manzardo to spring training.) |
| | 中外野手 | Non-roster Invitee (The Cleveland Guardians invited OF Petey Halpin to spring training.) |
| | 投手 | Non-roster Invitee (The Cleveland Guardians invited RHP Tanner Burns to spring training.) |
| | 捕手 | Traded (The Cleveland Guardians traded C Christian Bethancourt to the Miami Marlins.) 至 |
| | 捕手 | Signed (The Cleveland Guardians signed C Austin Hedges.) |
| | 投手 | Drafted Via Rule 5 (The Cleveland Guardians selected LHP John Doxakis in the Rule 5 Draft.) |
| | 三壘手 | Drafted Via Rule 5 (The Cleveland Guardians selected INF Deyvison De Los Santos in the Rule 5 Draft.) |
| | 右外野手 | Waived (The Cleveland Guardians waived OF Oscar Gonzalez.) |
| | 投手 | Signed (The Cleveland Guardians signed RHP Jaime Barría to a minor league contract.) |
| | 投手 | Signed (The Cleveland Guardians signed RHP Jaime Barría to a minor league contract.) |
| | 投手 | Traded (The San Diego Padres traded RHP Scott Barlow to the Cleveland Guardians.) 從 |
| | 捕手 | Traded (The Colorado Rockies traded C Kody Huff to the Cleveland Guardians.) 從 |
| | 投手 | Traded (The Cleveland Guardians traded RHP Cal Quantrill to the Colorado Rockies.) 至 |
| | 投手 | Traded (The Cleveland Guardians traded RHP Enyel De Los Santos to the San Diego Padres.) 至 |
| | 投手 | Signed (The Cleveland Guardians signed RHP Adam Oller to a minor league contract.) |
| | 投手 | Recalled From Minors Rehab (The Cleveland Guardians selected the contract of RHP Cade Smith from the minors.) |
| | 投手 | Designated for Assignment (The Cleveland Guardians designated RHP Cal Quantrill for assignment.) |
| | 投手 | Designated for Assignment (The Cleveland Guardians designated RHP Michael Kelly for assignment.) |
| | 投手 | Recalled From Minors Rehab (The Cleveland Guardians selected the contract of RHP Daniel Espino from the minors.) |
| | 捕手 | Declared Free Agency (C Cam Gallagher elected free agency.) |
| | 投手 | Declared Free Agency (RHP Sergio Morillo declared free agency.) |
| | 投手 | Declared Free Agency (RHP Jerad Eickhoff declared free agency.) |
| | 投手 | Declared Free Agency (RHP Luis Oviedo declared free agency.) |
| | 捕手 | Designated for Assignment (The Cleveland Guardians designated C Cam Gallagher for assignment.) |
| | 捕手 | Claimed on Unconditional Release Waivers (The Cleveland Guardians claimed C Christian Bethancourt off waivers from the Tampa Bay Rays.) |
| | 投手 | Activated (The Cleveland Guardians activated RHP Tanner Bibee.) |
| | 左外野手 | Activated (The Cleveland Guardians activated INF Jhonkensy Noel.) |
| | 投手 | Activated (The Cleveland Guardians activated LHP Joey Cantillo.) |
| | 投手 | Activated (The Cleveland Guardians activated LHP Logan Allen.) |
| | 二壘手 | Activated (The Cleveland Guardians activated INF Angel Martínez.) |
| | 右外野手 | Activated (The Cleveland Guardians activated OF George Valera.) |
| | 三壘手 | Activated (The Cleveland Guardians activated OF Gabriel Arias.) |
| | 投手 | Activated (The Cleveland Guardians activated LHP Tim Herrin.) |
| | 右外野手 | Recalled From Minors Rehab (The Cleveland Guardians recalled OF Johnathan Rodriguez from the minors.) |
| | 三壘手 | Activated (The Cleveland Guardians activated INF Juan Brito.) |
| | 投手 | Activated (The Cleveland Guardians activated RHP Hunter Gaddis.) |
| | 一壘手 | Activated (The Cleveland Guardians activated 1B David Fry.) |
| | 投手 | Activated (The Cleveland Guardians activated RHP Cody Morris.) |
| | 投手 | Activated (The Cleveland Guardians activated RHP Michael Kelly.) |
| | 捕手 | Declared Free Agency (Cleveland Guardians C Sandy León declared free agency.) |
| | 投手 | Declared Free Agency (Cleveland Guardians RHP Lucas Giolito declared free agency.) |
| | 一壘手 | Claimed on Unconditional Release Waivers (The Cleveland Guardians claimed INF Alfonso Rivas off waivers from the Pittsburgh Pirates.) |
| | 右外野手 | Declared Free Agency (Cleveland Guardians OF Kole Calhoun declared free agency.) |
| | 投手 | Declared Free Agency (Cleveland Guardians RHP Reynaldo López declared free agency.) |
| | 投手 | Declared Free Agency (RHP Zach Plesac declared free agency.) |
| | 投手 | Declared Free Agency (RHP Chris Vallimont declared free agency..) |
| | 投手 | Released (The Cleveland Guardians released LHP Daniel Norris.) |
| | 捕手 | Released (The Cleveland Guardians released C Zack Collins.) |
| | 捕手 | Released (The Cleveland Guardians released C Eric Haase.) |
| | 右外野手 | Recalled From Minors Rehab (The Cleveland Guardians recalled OF Oscar Gonzalez from the minors.) |
| | 一壘手 | Placed on Paternity Leave List (The Cleveland Guardians placed INF David Fry on the Paternity Leave list.) |
| | 三壘手 | Placed on 10-Day IL (The Cleveland Guardians placed OF Gabriel Arias on the 10-day injured list with a right wrist fracture.) |
| | 游擊手 | Recalled From Minors Rehab (The Cleveland Guardians recalled INF Brayan Rocchio from the minors.) |
| | 投手 | Sent to Minors (The Cleveland Guardians optioned RHP Michael Kelly to the minors.) |
| | 投手 | Activated (The Cleveland Guardians activated RHP Triston McKenzie from the 60-day injured list.) |
| | 投手 | Placed on 60-Day IL (The Cleveland Guardians placed RHP Tanner Bibee on the 60-day injured list.) |
| | 投手 | Recalled From Minors Rehab (The Cleveland Guardians recalled RHP Michael Kelly from the minors.) |
| | 投手 | Placed on 15-Day IL (The Cleveland Guardians placed LHP Logan Allen on the 15-day injured list with left shoulder inflammation. ) |
| | 投手 | Sent to Minors (The Cleveland Guardians optioned RHP Hunter Gaddis to the minors.) |
| | 投手 | Activated (The Cleveland Guardians activated RHP Shane Bieber from the 60-day injured list.) |
| | 投手 | Sent to Minors (The Cleveland Guardians optioned RHP Michael Kelly to the minors.) |
| | 投手 | Recalled From Minors Rehab (The Cleveland Guardians recalled RHP Hunter Gaddis from the minors.) |
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