| | OL | Claimed (The Jacksonville Jaguars claimed OL Jack Anderson off waivers.) 至 |
| | WR | Signed (The Indianapolis Colts signed WR Derek Slywka.) |
| | OL | Released (The Indianapolis Colts released OL Jack Anderson.) |
| | S | Placed on Injured Reserve (The Indianapolis Colts placed S Daniel Scott on IR.) |
| | CB | Signed (The Indianapolis Colts signed CB Clay Fields III.) |
| | WR | Signed (The Indianapolis Colts signed WR Adonai Mitchell.) |
| | WR | Signed (The Indianapolis Colts signed WR Adonai Mitchell.) |
| | WR | Signed (The Indianapolis Colts signed WR Anthony Gould.) |
| | OT | Signed (The Indianapolis Colts signed OT Matt Goncalvez.) |
| | OG | Signed (The Indianapolis Colts signed OG Tanor Bortolini.) |
| | DT | Signed (The Indianapolis Colts signed DT Jonah Laulu.) |
| | CB | Signed (The Indianapolis Colts signed CB Micah Abraham.) |
| | WR | Waived (The Indianapolis Colts waived WR Terrell Bynum.) |
| | CB | Signed (The Indianapolis Colts signed CB Jaylin Simpson.) |
| | LB | Signed (The Indianapolis Colts signed LB Jaylon Carlies.) |
| | DE | Signed (The Indianapolis Colts signed DE Laiatu Latu.) |
| | OL | Signed (The Indianapolis Colts signed OL Daniel Johnson.) |
| | OL | Signed (The Indianapolis Colts signed OL Aidan Hemphill.) |
| | WR | Signed (The Indianapolis Colts signed WR Dakota Caton.) |
| | DB | Signed (The Indianapolis Colts signed DB Brandon Bishop.) |
| | OT | Signed (The Indianapolis Colts signed OT Jake Hornibrook.) |
| | OL | Signed (The Indianapolis Colts signed OL Ben Farrell.) |
| | OL | Signed (The Indianapolis Colts signed OL Jake Kradel.) |
| | WR | Signed (The Indianapolis Colts signed WR Kaylon Horton.) |
| | DB | Signed (The Indianapolis Colts signed DB Devlin Kirklin.) |
| | S | Signed (The Indianapolis Colts signed S Julian Blackmon.) |
| | S | Declared Free Agent (S Julian Blackmon elected free agency.) |
| | DL | Declared Free Agent (DE Jake Martin elected free agency.) |
| | RB | Re-signed (The Indianapolis Colts re-signed RB Trey Sermon.) |
| | QB | Signed (The Indianapolis Colts signed QB Joe Flacco.) |
| | RB | Contract Expired (The Indianapolis Colts did not tender to a contract to RB Trey Sermon.) |
| | DT | Signed (The Indianapolis Colts signed DT Raekwon Davis.) |
| | RB | Declared Free Agent (RB Zack Moss elected free agency.) |
| | WR | Declared Free Agent (WR Isaiah McKenzie elected free agency.) |
| | QB | Declared Free Agent (QB Gardner Minshew elected free agency.) |
| | WR | Signed (The Buffalo Bills signed WR KJ Hamler to a reserve/futures deal.) 至 |
| | WR | Signed (The Indianapolis Colts signed WR Terrell Bynum to a reserve/future contract.) |
| | DT | Pract. squad add (The Houston Texans signed DL McTelvin Agim to the practice squad.) 至 |
| | S | Signed (The Las Vegas Raiders have signed S Tyreque Jones to a reserve/future contract.) 至 |
| | WR | Signed (The Indianapolis Colts signed WR Ethan Fernea to a reserve/future contract.) |
| | WR | Signed (The Indianapolis Colts signed WR Tyrie Cleveland to a reserve/future contract.) |
| | TE | Signed (The Indianapolis Colts signed TE Jordan Murray to a reserve/future contract.) |
| | S | Signed (The Indianapolis Colts signed DB Michael Tutsie to a reserve/future contract.) |
| | G | Signed (The Indianapolis Colts signed OL Lewis Kidd to a reserve/future contract.) |
| | TE | Signed (The Indianapolis Colts signed TE Eric Tomlinson to a reserve/future contract.) |
| | G | Signed (The Indianapolis Colts signed G Arlington Hambright to a reserve/future contract.) |
| | LB | Signed (The Indianapolis Colts signed LB Austin Ajiake to a reserve/future contract.) |
| | S | Signed (The Indianapolis Colts signed DB Kendell Brooks to a reserve/future contract.) |
| | LB | Signed (The Indianapolis Colts signed LB Liam Anderson to a reserve/future contract.) |
| | RB | Signed (The Indianapolis Colts signed WR Zavier Scott to a reserve/future contract.) |
| | DE | Activated (The Indianapolis Colts activated DE Al-Quadin Muhammad from suspension.) |
| | CB | Waived (The Indianapolis Colts waived CB Tony Brown.) |
| | TE | Pract. squad add (The Indianapolis Colts signed TE Eric Tomlinson to the practice squad.) |
| | WR | Signed (The Indianapolis Colts signed WR Juwann Winfree to the active roster.) |
| | WR | Activated (The Indianapolis Colts elevated WR Ethan Fernea to the active roster.) |
| | LB | Activated (The Indianapolis Colts elevated LB Liam Anderson to the active roster.) |
| | TE | Exempt/Commissioner's Permission List (Indianapolis Colts TE Andrew Ogletree was placed on the commissioner exempt permission list.) |
| | LB | Pract. squad add (The Indianapolis Colts signed LB Austin Ajiake to the practice squad.) |
| | S | Signed (The Indianapolis Colts signed DB Henry Black.) 從 |
| | S | Placed on Injured Reserve (The Indianapolis Colts placed DB Julian Blackmon on IR.) |
| | T | Activated (The Indianapolis Colts elevated OL Jared Veldheer to the active roster from the practice squad.) |
| | WR | Activated (The Indianapolis Colts elevated WR Ethan Fernea to the active roster from the practice squad.) |
| | CB | Signed (The Indianapolis Colts signed CB Chris Lammons to the active roster.) |
| | WR | Pract. squad add (The Indianapolis Colts signed WR Juwwann Winfree to the practice squad.) |
| | OLB | Pract. squad add (The Indianapolis Colts signed DE Zach McCloud to the practice squad.) |
| | CB | Team Suspension (The Indianapolis Colts suspended DB Tony Brown.) |
| | RB | Activated (The Indianapolis Colts signed RB Tyler Goodson to the active roster.) |
| | WR | Team Suspension (The Indianapolis Colts suspended WR Isaiah McKenzie.) |
| | G | Released (The Indianapolis Colts released G Lewis Kidd from the practice squad.) |
| | WR | Pract. squad add (The Indianapolis Colts sign WR Jaydon Mickens to the practice squad.) |
| | WR | Pract. squad add (The Indianapolis Colts assigned WR Ethan Fernea to the practice squad.) |
| | RB | Pract. squad add (The Indianapolis Colts assigned RB Tyler Goodson to the practice squad.) |
| | G | Pract. squad add (The Indianapolis Colts singed G Arlington Hambright to the practice squad. ) |
| | WR | Activated (The Indianapolis Colts elevated WR Ethan Fernea to the active roster.) |
| | RB | Activated (The Indianapolis Colts elevated RB Tyler Goodson to their active roster.) |
| | DE | Placed on Injured Reserve (The Indianapolis Colts have placed DE Derek Rivers on injured reserve.) |
| | G | Waived (The Indianapolis Colts waived OL Arlington Hambright.) |
| | WR | Activated (The Indianapolis Colts signed WR D.J. Montgomery to the active roster.) |
| | S | Released (The Indianapolis Colts released SAF Brandon Wilson.) |
| | WR | Pract. squad add (The Indianapolis Colts assigned WR D.J. Montgomery to the practice squad.) |
| | RB | Pract. squad add (The Indianapolis Colts assigned RB Tyler Goodson to the practice squad.) |
| | T | Pract. squad add (The Indianapolis Colts signed OT Jared Veldheer to the practice squad.) |
| | RB | Activated (The Indianapolis Colts elevated RB Tyler Goodson to the active roster from the practice squad.) |
| | WR | Waived (The Indianapolis Colts waived WR Juwann Winfree.) |
| | WR | Activated (The Indianapolis Colts elevated WR D.J. Montgomery to the active roster from the practice squad.) |
| | DE | Pract. squad add (The Indianapolis Colts signed DL Derek Rivers to the practice squad.) |
| | DE | Suspended (The NFL suspended DL Al-Quadin Muhammad for six games.) |
| | RB | Pract. squad add (The Indianapolis Colts assigned RB Tyler Goodson to the practice squad.) |
| | DT | Suspension lifted (DL Grover Stewart was reinstated from suspension.) |
| | WR | Pract. squad add (The Indianapolis Colts assigned WR D.J. Montgomery to the practice squad.) |
| | WR | Activated (The Indianapolis Colts elevated WR D.J. Montgomery to the active roster.) |
| | RB | Activated (The Indianapolis Colts elevated RB Tyler Goodson to the active roster.) |
| | WR | Placed on Injured Reserve (The Indianapolis Colts placed WR KJ Hamler on the practice squad IR.) |
| | WR | Pract. squad add (The Indianapolis Colts signed WR Ethan Fernea to the practice squad.) |