| | DT | Activated (The Buffalo Bills elevated DT Eli Ankou to the active roster.) |
| | WR | Activated (The Buffalo Bills elevated WR Jalen Virgil to the active roster.) |
| | K | Released (The Buffalo Bills released K Lucas Havrisik.) |
| | WR | Signed (The Buffalo Bills signed WR Deon Cain to the practice squad.) |
| | RB | Released (The Buffalo Bills released RB Darrynton Evans.) |
| | DT | Activated (The Buffalo Bills elevated DT Eli Ankou to the active roster.) |
| | WR | Activated (The Buffalo Bills elevated WR Jalen Virgil to the active roster.) |
| | DT | Placed on Injured Reserve (The Buffalo Bills placed DT DeWayne Carter on IR.) |
| | K | Pract. squad add (The Buffalo Bills signed K Lucas Havrisik to the practice squad.) |
| | WR | Released (The Buffalo Bills released WR Ahmarean Brown.) |
| | WR | Traded (The Cleveland Browns traded WR Amari Cooper to the Buffalo Bills.) 從 |
| | WR | Released (The Buffalo Bills released WR Marquez Valdes-Scantling.) |
| | RB | Activated (The Buffalo Bills elevated RB Frank Gore Jr. to the active from the practice squad.) |
| | DT | Pract. squad add (The Buffalo Bills assigned DT Branson Deen to the practice squad.) |
| | WR | Pract. squad add (The Buffalo Bills assigned WR Tyrell Shavers to the practice squad.) |
| | DT | Activated (The Buffalo Bills elevated DT Branson Deen to the active roster from the practice squad.) |
| | WR | Activated (The Buffalo Bills elevated WR Tyrell Shavers to the active roster from the practice squad.) |
| | LB | Suspended (The NFL suspended LB Von Miller for four games.) |
| | DT | Claimed (The Buffalo Bills claimed DT Zion Logue from the Atlanta Falcons practice squad.) 從 |
| | OT | Placed on Injured Reserve (The Buffalo Bills placed OL Tylan Grable on IR.) |
| | WR | Pract. squad add (The Buffalo Bills signed WR Ahmarean Brown to the practice squad.) |
| | OL | Signed (The Buffalo Bills signed OL Will Clapp to the active roster from the practice squad.) |
| | DE | Pract. squad add (The Buffalo Bills reverted DE Kingsley Jonathan back to the practice squad.) |
| | DE | Activated (The Buffalo Bills elevated DE Kingsley Jonathan to the active roster from the practice squad.) |
| | DE | Activated (The Buffalo Bills elevated DE Kameron Cline from the practice squad.) |
| | OL | Activated (The Buffalo Bills elevated OL Will Clapp from the practice squad.) |
| | S | Waived Injury (The Buffalo Bills waived SAF Terrell Burgess due to injury.) |
| | S | Waived Injury (The Buffalo Bills waived S Dee Delaney due to injury.) |
| | WR | Released (The Buffalo Bills released WR Deon Cain.) |
| | WR | Pract. squad add (The Buffalo Bills signed WR Jalen Virgil to the practice squad.) |
| | S | Pract. squad add (The Buffalo Bills signed S Kareem Jackson to the practice squad.) |
| | DE | Pract. squad add (The Buffalo Bills signed DE Kingsley Jonathan to the practice squad.) |
| | WR | Pract. squad add (The Buffalo Bills signed WR KJ Hamler to the practice squad.) |
| | DE | Pract. squad add (The Buffalo Bills signed DE Kameron Cline to the practice squad.) |
| | OT | Pract. squad add (The Buffalo Bills signed OL Richard Gouraige to the practice squad.) |
| | RB | Pract. squad add (The Buffalo Bills signed RB Frank Gore Jr. to the practice squad.) |
| | OL | Pract. squad add (The Buffalo Bills signed OL Mike Edwards to the practice squad.) |
| | DT | Pract. squad add (The Buffalo Bills signed DT Eli Ankou to the practice squad.) |
| | WR | Pract. squad add (The Buffalo Bills signed WR Tyrell Shavers to the practice squad.) |
| | DT | Pract. squad add (The Buffalo Bills signed DT Brandon Deen to the practice squad.) |
| | DB | Pract. squad add (The Buffalo Bills signed CB Te'Cory Couch to the practice squad.) |
| | CB | Pract. squad add (The Buffalo Bills signed CB Daequan Hardy to the practice squad.) |
| | OL | Pract. squad add (The Buffalo Bills signed OL Will Clap to the practice squad.) |
| | TE | Pract. squad add (The Buffalo Bills signed TE Zach Davidson to the practice squad.
) |
| | WR | Pract. squad add (The Buffalo Bills signed WR Deon Cain to the practice squad.) |
| | OL | Released (The Buffalo Bills released OL La'el Collins.) |
| | LB | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed LB Matt Milano on IRD.) |
| | RB | Waived (The Buffalo Bills waived RB Frank Gore.) |
| | QB | Released (The Buffalo Bills released QB Ben DiNucci.) |
| | OL | Released (The Buffalo Bills released OL Gunner Britton.) |
| | DE | Released (The Buffalo Bills released DE Kameron Cline.) |
| | CB | Released (The Buffalo Bills released CB Keni-H Lovely.) |
| | DT | Released (The Buffalo Bills released DT DeShawn Williams.) |
| | TE | Released (The Buffalo Bills released TE Tre' McKitty.) |
| | TE | Released (The Buffalo Bills released WR Justin Shorter.) |
| | DE | Released (The Buffalo Bills released DE Kingsley Jonathan.) |
| | DT | Released (The Buffalo Bills released DT Eli Ankou.) |
| | DB | Traded (The New York Jets traded CB Brandon Codrington to the Buffalo Bills.) 從 |
| | WR | Waived (The Buffalo Bills waived WR KJ Hamler.) |
| | OT | Released (The Buffalo Bills released T Richard Gouraige.) |
| | DT | Waived (The Buffalo Bills waived DT Gable Steveson.) |
| | DT | Released (The Buffalo Bills released DT Branson Deen.) |
| | RB | Placed on Injured Reserve, Designated for Return (The Buffalo Bills placed RB Darrynton Evans on IRD.) |
| | TE | Released (The Buffalo Bills released TE Zach Davidson.) |
| | DB | Released (The Buffalo Bills released CB Te'Cory Couch.) |
| | WR | Released (The Buffalo Bills released WR Tyrell Shavers.) |
| | WR | Released (The Buffalo Bills released WR Andy Isabella.) |
| | DB | Released (The Buffalo Bills released S Kendall Williamson.) |
| | OL | Released (The Buffalo Bills released OL Will Clapp.) |
| | WR | Released (The Buffalo Bills released WR Deon Cain.) |
| | OT | Placed on Injured Reserve (The Buffalo Bills placed OT Travis Clayton on IR.) |
| | WR | Released (The Buffalo Bills released WR Xavier Johnson.) |
| | CB | Released (The Buffalo Bills released CB Daequan Hardy.) |
| | OL | Released (The Buffalo Bills released OL Mike Edwards.) |
| | S | Released (The Buffalo Bills released S Kareem Jackson.) |
| | OL | Released (The Buffalo Bills released OL Keaton Bills.) |
| | WR | Released (The Buffalo Bills released WR Damiere Byrd.) |
| | QB | Released (The Buffalo Bills released QB Anthony Brown.) |
| | LB | Released (The Buffalo Bills released LB Shayne Simon.) |
| | DE | Released (The Buffalo Bills released DE Rondell Bothroyd.) |
| | CB | Released (The Buffalo Bills released CB Kyron Brown.) |
| | LB | Released (The Buffalo Bills released LB Deion Jones.) |
| | S | Placed on Injured Reserve (The Buffalo Bills placed S Dee Delaney on IR.) |
| | OL | Released (The Buffalo Bills released OL Kevin Jarvis.) |
| | S | Placed on Injured Reserve (The Buffalo Bills placed S Terrell Burgess on IR.) |
| | WR | Waived Injury (The Buffalo Bills waived WR Bryan Thompson due to injury.) |
| | WR | Waived Injury (The Buffalo Bills waived WR Lawrence Keys III due to injury.) |
| | QB | Signed (THe Buffalo Bills signed QB Anthony Brown Jr..) |
| | WR | Waived Injury (The Buffalo Bills waived WR Chase Claypool due to injury.) |
| | WR | Placed on Injured Reserve (The Buffalo Billis placed WR Bryan Thompson on IR after being waived due to injury.) |
| | WR | Signed (The Buffalo Bills signed WR Deon Cain.) |
| | WR | Signed (The Buffalo Bills signed WR Damiere Byrd.) |
| | WR | Waived Injury (The Buffalo Bills waived WR Bryan Thompson due to injury.) |
| | WR | Placed on Injured Reserve (The Buffalo Bills placrd WR Chase Claypool on IR.) |
| | QB | Placed on Injured Reserve (The Buffalo Bills placed QB Shane Buechele on IR.) |
| | QB | Signed (The Buffalo Bills signed QB Ben DiNucci.) |
| | DE | Placed on Injured Reserve (The Buffalo Bills placed DE David Ugwoegbu on IR after being waived due to injury.) |
| | LB | Signed (The Buffalo Bills signed LB Shayne Simon.) |
| | DE | Waived Injury (The Buffalo Bills waived DE David Ugwoegbu due to injury.) |
| | S | Signed (The Buffalo Bills signed S Terrell Burgess.) |
| | P | Waived (The Buffalo Bills waived P Jack Browning.) |
| | LB | Released (The Buffalo Bills released LB Shayne Simon.) |
| | S | Signed (The Buffalo Bills signed S Kareem Jackson.) |
| | WR | Signed (The Buffalo Bills signed WR Keon Coleman.) |
| | OT | Placed on PUPL (The Buffalo Bills placed OL Tommy Doyle on the Physically Unable to Perform list.) |
| | OL | Signed (The Buffalo Bills signed OL Sedrick Van Pran-Granger.) |
| | RB | Signed (The Buffalo Bills signed RB Ray Davis.) |
| | DT | Signed (The Buffalo Bills signed DT DeWayne Carter.) |
| | LB | Signed (The Buffalo Bills signed LB Shayne Simon.) |
| | OT | Waived Injury (The Buffalo Bills waived OL Tommy Doyle due to injury.) |
| | S | Signed (The Buffalo Bills signed S Cole Bishop.) |
| | OT | Signed (The Buffalo Bills signed OT Tylan Grable.) |
| | DE | Signed (The Buffalo Bills signed DE Javon Solomon.) |
| | CB | Signed (The Buffalo Bills signed CB Daequan Hardy.) |
| | LB | Signed (The Buffalo Bills signed LB Edefuan Ulofoshio.) |
| | DT | Signed (The Buffalo Bills signed DT Gable Steveson.) |
| | P | Released (The Buffalo Bills released P Matt Haack.) |
| | WR | Released (The Buffalo Bills released WR Quintez Cephus.) |
| | S | Signed (The Buffalo Bills signed S Dee Delaney.) |
| | WR | Signed (The Buffalo Bills signed WR Marquez Valdes-Scantling.) |
| | LB | Signed (The Buffalo Bills signed LB Joe Andreessen.) |
| | DE | Signed (The Buffalo Bills signed DT Rondell Bothroyd.) |
| | DE | Signed (The Buffalo Bills signed DE David Ugwoegbu.) |
| | OL | Signed (The Buffalo Bills signed OL Mike Edwards.) |
| | DB | Signed (The Buffalo Bills signed CB Te'Cory Couch.) |
| | OT | Signed (The Buffalo Bills signed OT Travis Clayton.) |
| | CB | Signed (The Buffalo Bills signed CB Travis Blackshear.) |
| | TE | Signed (The Buffalo Bills signed TE Mason Fairchild.) |
| | LB | Signed (The Buffalo Bills signed LB Kolbi Fuqua.) |
| | OL | Signed (The Buffalo Bills signed OL Michael Furtney.) |
| | DE | Signed (The Buffalo Bills signed DE Paul Nelson.) |
| | DL | Signed (The Buffalo Bills signed DL Devin Phillips.) |
| | DE | Signed (The Buffalo Bills signed OLB Dawuane Smoot.) |
| | WR | Signed (The Buffalo Bills signed WR Chase Claypool.) |
| | LB | Signed (The Buffalo Bills signed LB Deion Jones.) 從 |
| | CB | Signed (The Buffalo Bills signed CB Keni-H Lovely.) |
| | OL | Signed (The Buffalo Bills signed OL Gunner Britton.) |
| | QB | Signed (The Buffalo Bills signed QB Gunnar Watson.) |
| | DB | Signed (The Buffalo Bills signed S Alfahiym Walcott.) |
| | WR | Signed (The Buffalo Bills signed WR Xavier Johnson Jr.) |
| | RB | Signed (The Buffalo Bills signed RB Frank Gore Jr.) |
| | WR | Signed (The Buffalo Bills signed WR Lawrence Keys III.) |
| | OL | Signed (The Buffalo Bills signed OG Keaton Bills.) |
| | CB | Signed (The Buffalo Bills signed CB Sheridan Jones.) |
| | WR | Signed (The Buffalo Bills signed WR Quintez Cephus.) |
| | DT | Signed (The Buffalo Bills signed IDL Branson Deen.) |
| | P | Signed (The Buffalo Bills signed P Jack Browning.) |
| | DT | Signed (The New England Giants signed DT Jordan Phillips.) 至 |
| | OL | Signed (The Buffalo Bills signed OT La'el Collins.) |
| | WR | Traded (The Buffalo Bills traded WR Stefon Diggs to the Houston Texans.) 至 |
| | DT | Signed (The Buffalo Bills signed DT DeShawn Williams.) 從 |
| | QB | Declared Free Agent (QB Kyle Allen elected free agency.) |
| | RB | Retired (Buffalo Bills RB Damien Harris retired from the NFL.) |
| | DT | Signed (The Buffalo Bills signed DL Austin Johnson.) |
| | OL | Signed (The Buffalo Bills signed OL Will Clapp.) |
| | S | Signed (The Buffalo Bills signed S Mike Edwards.) 從 |
| | DE | Signed (The Buffalo Bills signed DE Casey Toohill.) |
| | LB | Declared Free Agent (LB Tyrel Dodson elected free agency.) |
| | WR | Declared Free Agent (WR Trent Sherfield elected free agency.) |
| | DT | Declared Free Agent (DT Tim Settle elected free agency.) |
| | WR | Signed (The Buffalo Bills signed WR Curtis Samuel.) |
| | DT | Declared Free Agent (Buffalo Bills DT Poona Ford declared free agency.) |
| | CB | Declared Free Agent (Buffalo Bills CB Dane Jackson declared free agency.) |
| | LB | Signed (The Buffalo Bills signed LB Nicholas Morrow.) |
| | WR | Signed (The Buffalo Bills signed WR Mack Hollins.) |
| | DL | Declared Free Agent (DE Leonard Floyd elected free agency.) |
| | WR | Declared Free Agent (WR Gabe Davis elected free agency.) |
| | DB | Released (The Buffalo Bills released CB Tre'Davious White.) |
| | S | Released (The Buffalo Bills released SAF Jordan Poyer.) |
| | QB | Signed (The Buffalo Bills signed QB Mitch Trubisky.) |
| | P | Re-signed (The Buffalo Bills re-signed P Matt Haack.) |
| | RB | Released (The Buffalo Bills released RB Nyheim Hines.) |
| | CB | Released (The Buffalo Bills released CB Siran Neal.) |
| | WR | Released (The Buffalo Bills released WR Deonte Harty.) |
| | OL | Released (The Buffalo Bills released C Mitch Morse.) |
| | OL | Traded (The Buffalo Bills traded OL Ryan Bates to the Chicago Bears.) 至 |
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